Skin Stem Cell And Skin Aging

The epidermis is a stratified squamous epithelium, composed of proliferating basal and differentiated suprabasal keratinocytes which acts as the body’s natural barrier to infection. The epidermis and skin appendages need to be renewed constantly to protect the body from dehydration, … Continue reading

Bookmark and Share

Age-Related Changes in Skin Epidermal-Dermal Junction

Structures at the Epidermal -Dermal junction (DEJ) derive their origin from the epidermis and dermis: the basal lamina is primarily of epidermal origin, the anchoring fibrils of dermal origin. The junction serves the following functions: (1) epidermal-dermal adherence, (2) mechanical … Continue reading

Bookmark and Share

The Role of Fibroblasts In Skin Aging

Fibroblasts are the most common cells of connective tissue that synthesizes the extracellular matrix and play a critical role in wound healing. Fibroblasts make and secrete collagens, elastin, ground substances such as glycosaminoglycans, glycoproteins found in the extracellular matrix and … Continue reading

Bookmark and Share

Types of Collagen In Skin Layer And In Skin Aging

What is Collagen Collagen, a group of naturally occurring proteins and the main component of connective tissue, is the most abundant protein making up 25% to 35% of the whole-body protein content. Collagen fibers (fine fibers about 1 nm in … Continue reading

Bookmark and Share

The Elastic System of Skin

While collagen is critical in maintaining healthy, youthful skin, there is another protein in the skin that is equally important for the health and appearance of skin – Elastin – a protein in connective tissue that is elastic and allows … Continue reading

Bookmark and Share

What Exactly Constitutes A Wrinkle?

A wrinkle is a fold, ridge or crease in the skin. Different intrinsic and external factors cause the development of a wrinkle. Biochemical and histological studies has revealed the pathogenesis of wrinkles. Significant biochemical changes contributed to the formation of … Continue reading

Bookmark and Share

The Histological Changes And The Clinical Features That Characterize Chronological Skin Aging and PhotoAging

The chronological skin aging is driven by the genetic programming – the programmed aging process that also makes the hair white and makes the teeth fall -. When the natural aging process is superimposed with photodamage, the skin ages much … Continue reading

Bookmark and Share

Enhanced Expression of Cylooxygenase-2(COX-2) In Chronological Skin Aging And Photoaging

Skin aging can be attributed to photoaging (extrinsic) and chronological (intrinsic) aging. Photoaging and intrinsic aging are induced by damage to human skin attributable to repeated exposure to ultraviolet (UV) irradiation and to the passage of time. COX-2 is a … Continue reading

Bookmark and Share

Is NF-kB the Secret to Skin Aging?

NF-κB is a protein complex that controls the transcription of DNA know as transcription factor which in turn regulate the expression of various genes. NF-κB is found in almost all cell types and is involved in cellular responses to stimuli … Continue reading

Bookmark and Share