Active Ingredients In
Anti-Aging Skin Care Topical Products:
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>> knowledge base /anti-aging skin care / active ingredients in anti-aging skin care products/ peptide / Argireline® Search Our Web Site Argireline® (Acetyl Hexapeptide-8)Acetyl Hexapeptide-8 Argireline®, [previously named Acetyl Hexapeptide 3], a patented ingredient, is a peptide attached with an acetyl group. Argireline® is manufactured by Lipotec Group (the same manufacturer for Snap-8, based in Spain) and distributed by Centerchem Inc. It is formulated to relax facial muscles by disrupting the nerve signals sent to tense muscles below the dermis, reduce the degree of existing wrinkles and stop their future development. It reduces the depth of wrinkles on the face caused by the contraction of muscles from facial expressions, especially around the eyes, mouth, and on the forehead. According to its official web site, "argireline® is a unique new anti-wrinkle peptide that has been shown to be significantly effective against the development of skin wrinkling, being a safer and milder alternative to Botulinum Toxin. This hexapeptide represents the discovery of a positive hit based on a scientific pathway from rational design to GMP production. The study of the basic biochemical mechanisms of anti-wrinkle activity has led to this Argireline® has been proved to work in vitro". Argireline® is a mimic of the N-terminal end of SNAP-25 and it competes with the natural protein for a position in the SNARE complex which is essential for the muscle contraction, so it destabilizes its formation, without breaking any of its components. If the SNARE complex is slightly destabilized, the vesicle cannot release neurotransmitters. As a consequence, muscle contraction is attenuated and the muscle is relaxed. According to Liptec official web site (http://www.the-argireline-site.com), The anti-wrinkle effect of argireline® was ascertained in two different in-vitro tests directly related to the formation of wrinkles in the epidermis as well as a separate in-vivo test performed in human volunteers. Argireline has been shown to moderate excessive catecholamines ( neurotransmitters or neuromodulators) release and a high inhibitory potencial of glutamate release in vitro. Reduction in the depth of wrinkles up to 17% after 15 days with 10% argireline® solution after in vivo clinical study. The depth of the furrow decreased a maximum value of 32% in 28 days with a cream containing 5% argireline® solution. The Recommended concentration: 3-10% (the disclosed stock solution contain 0.05% Acetyl Hexapeptide-8). Unlike Botox, Acetyl Hexapeptide-3 does not involve paralysis, toxins or side effects caused by leaked serum. It is non-invasive and safe for use in all areas of the face and throat (unlike Botox), and provides continuous, cumulative effects, which can ultimately last longer than Botox. Because Acetyl Hexapeptide-3 works more progressively, its effects are not as abrupt and noticeable as Botox injections and less likely to cause comment. This appeals to most women. LEUPHASYL® is Lipotec' s new product related to argireline® and Snap-8. This new peptide reduces expression wrinkles caused by the contraction of muscles of facial expression, especially in the forehead and around the eyes. LEUPHASYL® targets in vitro the formation mechanism of expression wrinkles in a new way. LEUPHASYL® has been designed to be used as a standalone product or as a complement to boost the efficacy of Lipotec's hugely succesful SNAP-25 analog peptides, such as ARGIRELINE®, SNAP-7 and SNAP-8. The following comments were extracted from cosmeticscop.com at the time of their writing. We believe Argireline® is working by reducing the excess release of neurotransmitters instead of totally shutting down the facial muscle contraction. "The truth of this claim about the effects of topical application of Argireline is based only on information from manufacturer, there is no published research substantiating any use of Argireline topically on skin. Catecholamines are compounds in the body that serve as neurotransmitters such as epinephrine, adrenaline, and dopamine. Epinephrine prepares the body to handle emergencies such as cold, fatigue, and shock. A deficiency of dopamine in the brain is responsible for the symptoms of Parkinson’s disease. These actions are not something you want a cosmetic to inhibit or reduce. If acetyl hexapeptide-3 really worked to relax facial muscles, it would work all over the face (assuming you’re using the products as directed). If all the muscles in your face were relaxed you’d have sagging, not youthful, skin, not to mention that it also would affect your hand (you apply it with your fingers), which would prevent you from picking up a cup or holding the steering wheel of your car. Despite all the fear about Botox that is espoused by companies featuring this peptide in their “works like Botox” products, there is considerably more efficacy, usage, and safety documentation available for Botox. Despite the claims made for acetyl hexapeptide-3 (Argireline), there is a clinical study that shows that this ingredient is not even remotely as effective as Botox in reducing wrinkles (Sources: www.cremedevie.com/clinical_details.htm; and International Journal of Cosmetic Science, October 2002). It is also interesting to note that even Botox when applied topically on skin has no impact on the skin or muscles in any way (Source: Cosmetic Dermatology, July 2005, pages 521–524.)" Related Pages: |
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Revised: 06/01/10.