UV-Induced Neutrophil Infiltration and Increased MMP Secretion in Photo Skin Aging

The primary mechanism of photo skin aging is mediated by UV induced reactive oxygen species (ROS). ROS damages biomacromolecules and function as intracellular signal to activate transcription factors AP-1 and NF-kB . AP-1 And NF-kB are known to regulate a … Continue reading

Bookmark and Share

The Endogenous Photoprotective Mechanisms In The Skin

UV-induced photo skin aging is primarily mediated via generation of reactive oxygen species/free radicals. Free radical theory of aging and skin aging is one of the most common causes of chronological and photo skin aging. UV irradiation not only activate … Continue reading

Bookmark and Share

Age-Related Morphological, Histological, Structural, And Molecular Changes In Skin Fibroblast In Vitro

The study of age-related changes in the physiology, biochemistry, and molecular biology of isolated skin cell populations in culture has expanded and provide the basis for the understanding of the fundamental aspects of skin aging. In the field of molecular … Continue reading

Bookmark and Share

Mechanism of UV Induced ROS Generation: Photosensitization

The primary mechanism of UV induced skin aging is the production and generation of reactive oxygen species (ROS). ROS/free radicals is one of the main causes of chronologic and photo skin aging. ROS damages and oxidizes biomacromolecules and cellular components. … Continue reading

Bookmark and Share

The Effect of UV-Induced Gene Activation On Photo Skin Aging

The primary mechanism of UV-induced skin aging is mediated by the generation and accumulation of free radicals including reactive oxygen species (ROS) and reactive nitrogen species (RNS). ROS or free radicals not only can damage proteins, DNA, cellular membrane and … Continue reading

Bookmark and Share

Mechanism of UV Induced ROS Generation: NADPH Oxidase Activation

The primary mechanism of UV induced skin aging is the production and generation of reactive oxygen species (ROS). ROS/free radicals is one of the main causes of chronologic and photo skin aging . ROS exerts aging effect via damaging and … Continue reading

Bookmark and Share

The Nonenzymatic Antioxidant Systems In Aging Skin

The free radical theory of aging established the role of oxidative stress as one of the main causes of aging and skin aging. Reactive oxygen species (ROS) – produced as byproduct of oxidative energy metabolism and induced by external factors … Continue reading

Bookmark and Share

ROS and UV Induced Mitochondria DNA Mutation and Common Deletion In Skin

Mitochondria are cellular organelles that produce energy (ATP) by consuming oxygen. In the chronological aging process, mitochondria not only produce less ATP, but they also increase the production of reactive oxygen species (ROS) as by-products of aerobic metabolism, particularly during … Continue reading

Bookmark and Share

NF-kB and AP-1 Molecular Signaling Mechanisms of Intrinsic And Extrinsic Skin Aging

The molecular signaling pathways associated with skin aging is most and initially studied in the photo skin aging. Numerous researches published combined the pieces of discovery into an general overview picture about what occurred molecularly in photo skin aging. It … Continue reading

Bookmark and Share

AP-1 Signaling Activates MMP in Chronological and Photo Skin Aging

The activator protein 1 (AP-1) is a heterodimeric transcription factor belonging to the c-Fos, c-Jun, ATF and JDP families. It regulates and activates genes in response to a variety of stimuli including stress, pathogen infections, cytokines, growth factors. AP-1 thereby … Continue reading

Bookmark and Share